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pentobarbital will decrease the extent or outcome of parecoxib by influencing hepatic enzyme CYP2C9/10 metabolism. Use Warning/Check.pentobarbital will reduce the extent or impact of tramadol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Diminished AUC of tramadol plus the active metabolite (O-desmethyltramadol) w